Thyroid hormone-induced chondrocyte terminal differentiation in rat femur organ culture
Identifieur interne : 003B11 ( Main/Exploration ); précédent : 003B10; suivant : 003B12Thyroid hormone-induced chondrocyte terminal differentiation in rat femur organ culture
Auteurs : R. Wakita ; Toshihiro Izumi ; Moritoshi ItomanSource :
- Cell and Tissue Research [ 0302-766X ] ; 1998-07-01.
English descriptors
- KwdEn :
Abstract
Abstract : Thyroid hormone plays a role in skeletal maturation. The present study was undertaken to investigate the effect of thyroid hormone on growth and maturation of the epiphyseal cartilage in the rat femur organ culture system. The femora increased in both weight and size over time in culture in the absence of serum. The growth rate was suppressed by thyroxine treatment. Thyroxine induced chondrocyte hypertrophy in the area adjacent to the articular surface in the femoral condyle. In this area, the expression of type X collagen, a marker of chondrocyte terminal differentiation, was detected after 21 days in culture by immunohistochemistry and reverse transcription/polymerase chain reaction. These data suggest that thyroxine suppresses cartilage growth by stimulating chondrocyte terminal differentiation.
Url:
DOI: 10.1007/s004410051127
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000D10
- to stream Istex, to step Curation: 000D10
- to stream Istex, to step Checkpoint: 001320
- to stream Main, to step Merge: 003B60
- to stream Main, to step Curation: 003B11
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Thyroid hormone-induced chondrocyte terminal differentiation in rat femur organ culture</title><author><name sortKey="Wakita, R" sort="Wakita, R" uniqKey="Wakita R" first="R." last="Wakita">R. Wakita</name></author><author><name sortKey="Izumi, Toshihiro" sort="Izumi, Toshihiro" uniqKey="Izumi T" first="Toshihiro" last="Izumi">Toshihiro Izumi</name></author><author><name sortKey="Itoman, Moritoshi" sort="Itoman, Moritoshi" uniqKey="Itoman M" first="Moritoshi" last="Itoman">Moritoshi Itoman</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1E7763A283FE4F6FE030BDBE357CB0DA963A6073</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1007/s004410051127</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-QDZW395B-C/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000D10</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000D10</idno><idno type="wicri:Area/Istex/Curation">000D10</idno><idno type="wicri:Area/Istex/Checkpoint">001320</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001320</idno><idno type="wicri:doubleKey">0302-766X:1998:Wakita R:thyroid:hormone:induced</idno><idno type="wicri:Area/Main/Merge">003B60</idno><idno type="wicri:Area/Main/Curation">003B11</idno><idno type="wicri:Area/Main/Exploration">003B11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Thyroid hormone-induced chondrocyte terminal differentiation in rat femur organ culture</title><author><name sortKey="Wakita, R" sort="Wakita, R" uniqKey="Wakita R" first="R." last="Wakita">R. Wakita</name><affiliation><wicri:noCountry code="subField">JP</wicri:noCountry></affiliation></author><author><name sortKey="Izumi, Toshihiro" sort="Izumi, Toshihiro" uniqKey="Izumi T" first="Toshihiro" last="Izumi">Toshihiro Izumi</name><affiliation><wicri:noCountry code="subField">JP</wicri:noCountry></affiliation></author><author><name sortKey="Itoman, Moritoshi" sort="Itoman, Moritoshi" uniqKey="Itoman M" first="Moritoshi" last="Itoman">Moritoshi Itoman</name><affiliation><wicri:noCountry code="subField">JP</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Cell and Tissue Research</title><title level="j" type="abbrev">Cell Tissue Res</title><idno type="ISSN">0302-766X</idno><idno type="eISSN">1432-0878</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1998-07-01">1998-07-01</date><biblScope unit="volume">293</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="357">357</biblScope><biblScope unit="page" to="364">364</biblScope></imprint><idno type="ISSN">0302-766X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0302-766X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cartilage</term><term>Differentiation</term><term>Key words Thyroxine</term><term>Organ culture</term><term>Rat (Wistar)</term><term>Type X collagen</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract : Thyroid hormone plays a role in skeletal maturation. The present study was undertaken to investigate the effect of thyroid hormone on growth and maturation of the epiphyseal cartilage in the rat femur organ culture system. The femora increased in both weight and size over time in culture in the absence of serum. The growth rate was suppressed by thyroxine treatment. Thyroxine induced chondrocyte hypertrophy in the area adjacent to the articular surface in the femoral condyle. In this area, the expression of type X collagen, a marker of chondrocyte terminal differentiation, was detected after 21 days in culture by immunohistochemistry and reverse transcription/polymerase chain reaction. These data suggest that thyroxine suppresses cartilage growth by stimulating chondrocyte terminal differentiation.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Itoman, Moritoshi" sort="Itoman, Moritoshi" uniqKey="Itoman M" first="Moritoshi" last="Itoman">Moritoshi Itoman</name><name sortKey="Izumi, Toshihiro" sort="Izumi, Toshihiro" uniqKey="Izumi T" first="Toshihiro" last="Izumi">Toshihiro Izumi</name><name sortKey="Wakita, R" sort="Wakita, R" uniqKey="Wakita R" first="R." last="Wakita">R. Wakita</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003B11 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003B11 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:1E7763A283FE4F6FE030BDBE357CB0DA963A6073
|texte= Thyroid hormone-induced chondrocyte terminal differentiation in rat femur organ culture
}}
| This area was generated with Dilib version V0.6.33. |  |